There's science backing it. Whether or not you can "spot reduce" to a degree that makes it worthwhile is an entirely different matter.

There is science backing the idea that you can possibly increase lipolysis (fat breakdown) in a specific area. However, lipolysis (breakdown) doesn't necessarily equal oxidation (burning) of fat. It can either be redistributed or even replaced where it was.

I was assuming we were targeting while in a deficit :-P

chicken

egg

There was an earlier article posted here, where someone attended a BioSig course and the verdict was that it works... but the supplementation regime is hell expensive. Coming to a few hundred dollars a month, if memory serves correct.

I've taken the biosig course and the is no scientific evidence (at this point) to back up Poliquin's claims. And frankly, I have to agree that it will "work" if you're in a calorie deficit as you'll lose fat at every site you measure.

I once used a topical yohimbine product that I used on one man boob and not on the other. The yohimbine man boob lost a visually higher amount of fat than the control moob. I didn't think it would work, but it did. And yes, I did use it on the other side of my chest to even it all out. Furthermore, when I switched from cutting to bulking, the sites where I originally lost the fat seemed to fill in quicker than the rest of my body. True story.

...Interesting

I used capsacin + lipoderm ultra for competition twice (this was probably the most painful thing I've ever felt). Every single time, my lower chest didn't start to lean out until I used it, and both times I used it at a different bodyfat %.